HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025.
SignificanceNarcolepsy type 1 is remarkable for its strong transethnic association with human leukocyte antigen (HLA)-DQA1*01:02/DQB1*06:02; only a handful of cases without these alleles have been found. Variation at HLA-DQA1 eliminates susceptibility, …

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